Jäger, Anna-Thekla; Steele, C.; Dreyer, F. R.; Osterloh, M. R.; Sadlon, A.; Nikulin, V. V.; Mohr, B.; & Pulvermüller, F. (2025). BOLD long-range temporal correlations reflect changes in language and depression across intensive aphasia therapy. Stroke, 56(11), 3138–3152. https://doi.org/10.1161/STROKEAHA.124.050064

Intensive language-action therapy treats language deficits and depressive symptoms in chronic poststroke
aphasia, yet the underlying neural mechanisms remain underexplored. Long-range temporal correlations (LRTC) in blood
oxygenation level–dependent signals indicate persistence in brain activity patterns and may relate to learning and levels
of depression. This observational study investigates blood oxygenation level–dependent LRTC changes alongside therapy-
induced language and mood improvements in perisylvian and domain-general brain areas.