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What’s “up”? Impaired Spatial Preposition Processing in Posterior Cortical Atrophy

Zubaida Shebani, Peter J. Nestor, Friedemann Pulvermüller – 2021

This study seeks to confirm whether lesions in posterior regions of the brain involved in visuo-spatial processing are of functional relevance to the processing of words with spatial meaning. We investigated whether patients with Posterior Cortical Atrophy (PCA), an atypical form of Alzheimer’s Disease which predominantly affects parieto-occipital brain regions, is associated with deficits in working memory for spatial prepositions. Case series of patients with PCA and matched healthy controls performed tests of immediate and delayed serial recall on words from three lexico-semantic word categories: number words (twelve), spatial prepositions (behind) and function words (e.g., shall). The three word categories were closely matched for a number of psycholinguistic and semantic variables including length, bi-/tri-gram frequency, word frequency, valence and arousal. Relative to controls, memory performance of PCA patients on short word lists was significantly impaired on spatial prepositions in the delayed serial recall task. These results suggest that lesions in posterior parieto-occipital regions specifically impair the processing of spatial prepositions. Our findings point to a pertinent role of posterior cortical regions in the semantic processing of words with spatial meaning and provide strong support for modality-specific semantic theories that recognize the necessary contributions of sensorimotor regions to conceptual semantic processing.

Title
What’s “up”? Impaired Spatial Preposition Processing in Posterior Cortical Atrophy
Publisher
Frontiers in Human Neuroscience
Keywords
posterior cortical atrophy, PCA, working memory, semantic processing, embodiment cognition, spatial prepositions, spatial language processing, category specific impairments
Date
2021-12-01
Identifier
https://doi.org/10.3389/fnhum.2021.731104
Language
eng
Type
Text
BibTeX Code
@ARTICLE{10.3389/fnhum.2021.731104,

AUTHOR={Shebani, Zubaida and Nestor, Peter J. and Pulvermüller, Friedemann},

TITLE={What’s “up”? Impaired Spatial Preposition Processing in Posterior Cortical Atrophy},

JOURNAL={Frontiers in Human Neuroscience},

VOLUME={15},

YEAR={2021},

URL={https://www.frontiersin.org/article/10.3389/fnhum.2021.731104},

DOI={10.3389/fnhum.2021.731104},

ISSN={1662-5161},

ABSTRACT={This study seeks to confirm whether lesions in posterior regions of the brain involved in visuo-spatial processing are of functional relevance to the processing of words with spatial meaning. We investigated whether patients with Posterior Cortical Atrophy (PCA), an atypical form of Alzheimer’s Disease which predominantly affects parieto-occipital brain regions, is associated with deficits in working memory for spatial prepositions. Case series of patients with PCA and matched healthy controls performed tests of immediate and delayed serial recall on words from three lexico-semantic word categories: number words (twelve), spatial prepositions (behind) and function words (e.g., shall). The three word categories were closely matched for a number of psycholinguistic and semantic variables including length, bi-/tri-gram frequency, word frequency, valence and arousal. Relative to controls, memory performance of PCA patients on short word lists was significantly impaired on spatial prepositions in the delayed serial recall task. These results suggest that lesions in posterior parieto-occipital regions specifically impair the processing of spatial prepositions. Our findings point to a pertinent role of posterior cortical regions in the semantic processing of words with spatial meaning and provide strong support for modality-specific semantic theories that recognize the necessary contributions of sensorimotor regions to conceptual semantic processing.}
}
Cordis
ERC